One dark, lonely night in 1977, an agent with the F.B.I fights desperately for his life and looses. Twenty years later, the story of his unsolved murder sits quietly in Special Agent Fox Mulder's file cabinet. A strange man dredges the story back up to the surface, causing Mulder to revisit the old case-file.

Though reluctant, Special Agent Dana Scully follows her partner once again into the unknown. This strange case of a twenty year old unsolved murder of an F.B.I Agent will take Mulder and Scully farther south than they've ever been - The Amazon river basin of South America. Along with a hand-picked group of professionals, they trudge through the Amazon to make a date with destiny.